Aid in the Improvement of Acetylcholine Signaling / Huperzine A
Acetylcholine is one of the most abundant neurotransmitters in the human body. It can be found in the central and peripheral nervous systems. And its name was derived from its structure, being made up of acetic acid and choline.
Acetylcholine is crucial to all functions of the body. It is present in all motor neurons, where it stimulates muscle contraction. This neurotransmitter is essential to every movement in our bodies, from the minute blink of an eye, to the beating of our hearts, to the movement of our limbs.
Acetylcholine is also found in many brain neurons, where it facilitates memory and other cognitive activities. Alzheimer's disease is indicated when someone has severely depleted acetylcholine.
This was the first neurotransmitter to be identified in the brain, discovered in 1914 by Henry Hallett Dale.
This neurotransmitter is also a neuromodulator (a messenger molecule that nerve cells release so it can signal and regulate other nerve cells). It plays an essential role in the cognitive functions of the brain, like arousal, attention, motivation, learning, and especially in the process of memory.
Additionally, acetylcholine plays the largest role of any neurotransmitter in REM sleep.
Huperzine-A is involved in acetylcholine signaling, which is one of it’s most widely known roles biologically. In animal and human studies, Huperzine-A has shown its ability to boost acetylcholine levels which influences the activities of the enzyme cholinesterase.
Overall, it increases acetylcholine significantly. Its involvement with acetylcholine signaling explains its importance in the functions of memory and cognition.
Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587556/
NuBrainer
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trader32176
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trader32176
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Re: NuBrainer
Understanding the Function and Benefits of Huperzine A
https://neurohacker.com/understanding-t ... uperzine-a
https://neurohacker.com/understanding-t ... uperzine-a
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TimGDixon
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Re: NuBrainer
NuBrainer is now available https://www.youcanordernow.com/NuBraine ... _p_40.html
“...never interrupt your enemy when he is making mistakes...”
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TradersTrader
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Re: NuBrainer
Congratulations, Tim!! 
Will NanoStilbene Cream be available soon? Looks like a great response so far. I know a few people that would like to try it (family and a few concrete contractors)
QuadraMune/NS has made believers of many
Will NanoStilbene Cream be available soon? Looks like a great response so far. I know a few people that would like to try it (family and a few concrete contractors)
QuadraMune/NS has made believers of many
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TradersTrader
- Posts: 121
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Re: NuBrainer
I just saw that 10Q wont be filed for QTR ending March 31,2022. May be we wont get to see the financials until June then....
I am well wisher of everyone! GOD will pardon all your sins but not your Central Nervous System! Think Positive!
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TimGDixon
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Re: NuBrainer
June? no. in a few days it will be out.
“...never interrupt your enemy when he is making mistakes...”
Re: NuBrainer
Thats good that we are ready for compliance all the time! 
Any comments on today NEWS on new drug for type 2 diabetes from Eily Lilly? FDA approves Lilly diabetes drug that analysts expect to be a big seller https://www.statnews.com/2022/05/13/fda ... e%20weight.
Mounjaro delivered superior A1C reductions versus all comparators in phase 3 SURPASS clinical trials
While not indicated for weight loss, Mounjaro led to significantly greater weight reductions versus comparators in a key secondary endpoint
Mounjaro represents the first new class of diabetes medicines introduced in nearly a decade and is expected to be available in the U.S. in the coming weeks
INDIANAPOLIS, May 13, 2022 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) approved Mounjaro™ (tirzepatide) injection, Eli Lilly and Company's (NYSE: LLY) new once-weekly GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. Mounjaro has not been studied in patients with a history of pancreatitis and is not indicated for use in patients with type 1 diabetes mellitus.
As the first and only FDA-approved GIP and GLP-1 receptor agonist, Mounjaro is a single molecule that activates the body's receptors for GIP and GLP-1, which are natural incretin hormones.1
"Mounjaro delivered superior and consistent A1C reductions against all of the comparators throughout the SURPASS program, which was designed to assess Mounjaro's efficacy and safety in a broad range of adults with type 2 diabetes who could be treated in clinical practice. The approval of Mounjaro is an exciting step forward for people living with type 2 diabetes given the results seen in these clinical trials," said Juan Pablo Frías, M.D., Medical Director, National Research Institute and Investigator in the SURPASS program.
Mounjaro will be available in six doses (2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg) and will come in Lilly's well-established auto-injector pen with a pre-attached, hidden needle that patients do not need to handle or see.
The approval was based on results from the phase 3 SURPASS program, which included active comparators of injectable semaglutide 1 mg, insulin glargine and insulin degludec. Efficacy was evaluated for Mounjaro 5 mg, 10 mg and 15 mg used alone or in combination with commonly prescribed diabetes medications, including metformin, SGLT2 inhibitors, sulfonylureas and insulin glargine. Participants in the SURPASS program achieved average A1C reductions between 1.8% and 2.1% for Mounjaro 5 mg and between 1.7% and 2.4% for both Mounjaro 10 mg and Mounjaro 15 mg. While not indicated for weight loss, mean change in body weight was a key secondary endpoint in all SURPASS studies. Participants treated with Mounjaro lost between 12 lb. (5 mg) and 25 lb. (15 mg) on average.1
Side effects reported in at least 5% of patients treated with Mounjaro include nausea, diarrhea, decreased appetite, vomiting, constipation, indigestion (dyspepsia), and stomach (abdominal) pain. The labeling for Mounjaro contains a Boxed Warning regarding thyroid C-cell tumors. Mounjaro is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2.1
"Lilly has a nearly 100-year heritage of advancing care for people living with diabetes – never settling for current outcomes. We're not satisfied knowing that half of the more than 30 million Americans living with type 2 diabetes are not reaching their target blood glucose levels," said Mike Mason, president, Lilly Diabetes. "We are thrilled to introduce Mounjaro, which represents the first new class of type 2 diabetes medication introduced in almost a decade and embodies our mission to bring innovative new therapies to the diabetes community."
Any comments on today NEWS on new drug for type 2 diabetes from Eily Lilly? FDA approves Lilly diabetes drug that analysts expect to be a big seller https://www.statnews.com/2022/05/13/fda ... e%20weight.Mounjaro delivered superior A1C reductions versus all comparators in phase 3 SURPASS clinical trials
While not indicated for weight loss, Mounjaro led to significantly greater weight reductions versus comparators in a key secondary endpoint
Mounjaro represents the first new class of diabetes medicines introduced in nearly a decade and is expected to be available in the U.S. in the coming weeks
INDIANAPOLIS, May 13, 2022 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) approved Mounjaro™ (tirzepatide) injection, Eli Lilly and Company's (NYSE: LLY) new once-weekly GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. Mounjaro has not been studied in patients with a history of pancreatitis and is not indicated for use in patients with type 1 diabetes mellitus.
As the first and only FDA-approved GIP and GLP-1 receptor agonist, Mounjaro is a single molecule that activates the body's receptors for GIP and GLP-1, which are natural incretin hormones.1
"Mounjaro delivered superior and consistent A1C reductions against all of the comparators throughout the SURPASS program, which was designed to assess Mounjaro's efficacy and safety in a broad range of adults with type 2 diabetes who could be treated in clinical practice. The approval of Mounjaro is an exciting step forward for people living with type 2 diabetes given the results seen in these clinical trials," said Juan Pablo Frías, M.D., Medical Director, National Research Institute and Investigator in the SURPASS program.
Mounjaro will be available in six doses (2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg) and will come in Lilly's well-established auto-injector pen with a pre-attached, hidden needle that patients do not need to handle or see.
The approval was based on results from the phase 3 SURPASS program, which included active comparators of injectable semaglutide 1 mg, insulin glargine and insulin degludec. Efficacy was evaluated for Mounjaro 5 mg, 10 mg and 15 mg used alone or in combination with commonly prescribed diabetes medications, including metformin, SGLT2 inhibitors, sulfonylureas and insulin glargine. Participants in the SURPASS program achieved average A1C reductions between 1.8% and 2.1% for Mounjaro 5 mg and between 1.7% and 2.4% for both Mounjaro 10 mg and Mounjaro 15 mg. While not indicated for weight loss, mean change in body weight was a key secondary endpoint in all SURPASS studies. Participants treated with Mounjaro lost between 12 lb. (5 mg) and 25 lb. (15 mg) on average.1
Side effects reported in at least 5% of patients treated with Mounjaro include nausea, diarrhea, decreased appetite, vomiting, constipation, indigestion (dyspepsia), and stomach (abdominal) pain. The labeling for Mounjaro contains a Boxed Warning regarding thyroid C-cell tumors. Mounjaro is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2.1
"Lilly has a nearly 100-year heritage of advancing care for people living with diabetes – never settling for current outcomes. We're not satisfied knowing that half of the more than 30 million Americans living with type 2 diabetes are not reaching their target blood glucose levels," said Mike Mason, president, Lilly Diabetes. "We are thrilled to introduce Mounjaro, which represents the first new class of type 2 diabetes medication introduced in almost a decade and embodies our mission to bring innovative new therapies to the diabetes community."
I am well wisher of everyone! GOD will pardon all your sins but not your Central Nervous System! Think Positive!
Re: NuBrainer
Tim, A couple of questions if you have time,
First, when you were recruiting for the Pilot study, you mentioned possible altering the mix based on what supplements people were already taking ( I believe it mainly concerned QM). Should I alter my intake? 170 lb male 62yrs, active and on low calorie diet, currently taking 2 Nubrainer and 3 QM per day.
Second, you mentioned that one of the key ingredients was a precurser that was activated during digestion, hence taking with food. Will ANY food do?
Third, My 82 yr old mother in law and a sister in law will be moving in with us from Ukraine. I plan on having her start on QM ( mainly for arthritis and energy level) and Nubrainer. Given her reduced metabolism, decreased activity level, and low calorie diet, should her intake vary from recommended levels?
Fourth, My sister in law had a digestive problem that required surgery at age 3. There was a complication with the anesthesia and her brained was deprived of oxygen for an extended period. She is 56 now, but with the mind of a 4-5 yr old. Is there any possibility Nibrainer would be of any benefit? I'm willing to try, but we are on a fixed budget. We will be selling our house this summer and moving into a rental in Fairbanks, to better accommodate their needs and reduce our costs. If you believe it will help, I will, of course, spend the money, just don't want to waste it if it's out of the realm of possibility.
Last, but not least, I would like to volunteer when you start trials for PTSD/concussion/ traumatic brain injury. I'm sure that after living in close quarters with 3 crazy Ukrainian women ( and a Russian Blue cat) my brain chemistry will be altered and I will be in need of help. I suggested buying large quantities of Ukranian Vodka to help support the Ukranian economy, but my wife isn't buying it!
First, when you were recruiting for the Pilot study, you mentioned possible altering the mix based on what supplements people were already taking ( I believe it mainly concerned QM). Should I alter my intake? 170 lb male 62yrs, active and on low calorie diet, currently taking 2 Nubrainer and 3 QM per day.
Second, you mentioned that one of the key ingredients was a precurser that was activated during digestion, hence taking with food. Will ANY food do?
Third, My 82 yr old mother in law and a sister in law will be moving in with us from Ukraine. I plan on having her start on QM ( mainly for arthritis and energy level) and Nubrainer. Given her reduced metabolism, decreased activity level, and low calorie diet, should her intake vary from recommended levels?
Fourth, My sister in law had a digestive problem that required surgery at age 3. There was a complication with the anesthesia and her brained was deprived of oxygen for an extended period. She is 56 now, but with the mind of a 4-5 yr old. Is there any possibility Nibrainer would be of any benefit? I'm willing to try, but we are on a fixed budget. We will be selling our house this summer and moving into a rental in Fairbanks, to better accommodate their needs and reduce our costs. If you believe it will help, I will, of course, spend the money, just don't want to waste it if it's out of the realm of possibility.
Last, but not least, I would like to volunteer when you start trials for PTSD/concussion/ traumatic brain injury. I'm sure that after living in close quarters with 3 crazy Ukrainian women ( and a Russian Blue cat) my brain chemistry will be altered and I will be in need of help. I suggested buying large quantities of Ukranian Vodka to help support the Ukranian economy, but my wife isn't buying it!
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TimGDixon
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Re: NuBrainer
When I was a little boy (5 or 6 maybe) I hid under my mothers piano and waited all night for Santa and I swore I saw him.. i was likely dreaming but I saw him.. i know I did, and now he's posting on my forum. You have been bringing me presents my whole life so let me see if I can give back a little.
1) This has to do with pterostilbene intake and my recommendation is 2QM and 2NB. Otherwise you waste 100mg of pterostilbene but it won't hurt you.
2) Actually QM, NB, ProJuvenol, and NLRP3 Trifecta all work better if you take with a little food. It can be a full blown meal or an english muffin. When your body digests actual food the maximum numbers of enzymes, bacterias, and acids are in play and that will help getting full metabolism vs taking them with a glass of water.
3) I think low and slow is the way to go when introducing potent immune stimulants like ours are. I would perhaps consider a partial dose of both QM and NB as one capsule each. Slowly increasing to full dose which would be 2 + 2.
4) This is a hard one. I would like to think about this more.
5) I would be thrilled for you be in some clinical trial but your data would most likely be disqualified because of your relationship with me/tsoi. You know we are developing protocols for use in this area with JadiCells. The Navy SEALS (Ret.) have provided us valuable data and so a time may come when we can see about helping you under RTT. In the meantime I think the vodka will help some....
1) This has to do with pterostilbene intake and my recommendation is 2QM and 2NB. Otherwise you waste 100mg of pterostilbene but it won't hurt you.
2) Actually QM, NB, ProJuvenol, and NLRP3 Trifecta all work better if you take with a little food. It can be a full blown meal or an english muffin. When your body digests actual food the maximum numbers of enzymes, bacterias, and acids are in play and that will help getting full metabolism vs taking them with a glass of water.
3) I think low and slow is the way to go when introducing potent immune stimulants like ours are. I would perhaps consider a partial dose of both QM and NB as one capsule each. Slowly increasing to full dose which would be 2 + 2.
4) This is a hard one. I would like to think about this more.
5) I would be thrilled for you be in some clinical trial but your data would most likely be disqualified because of your relationship with me/tsoi. You know we are developing protocols for use in this area with JadiCells. The Navy SEALS (Ret.) have provided us valuable data and so a time may come when we can see about helping you under RTT. In the meantime I think the vodka will help some....
“...never interrupt your enemy when he is making mistakes...”
Re: NuBrainer
GREAT!! I'll tell the wife you recommended the vodka!!
As far as my sister in law, I can't really give any details. Ukranian medicine is not very open with information/ patent care. Two examples, my father in law had a stroke a year ago, and because they couldn't prove he didn't have Covid, they wouldn't admit him into the cardio wing, so he died a few days later from not receiving attention soon enough. Also, when giving birth, the baby is taken from the mother immediately, and the mother is isolated for 3-5 days. She can't see the baby or family. If she is lucky ( like my wife) and is on the ground floor with a window, her family can at least stand on the lawn and look in the window to see her, but not the baby. Needless to say, they never fully explained what exactly happened during the surgery and what, exactly, the brain damage was. She can function for typical everyday things like washing dishes and going to the store to buy treats, but has no concept of war and it's inherent dangers and why she is having to leave her home move to the US. She seems to have a high pain threshold. She didn't complain about her shoulder hurting until it was so bad it required reconstructive surgery, and didn't say anything about her teeth until her jaw was too badly damaged to accept normal dental implants. I understand Nubrainer cannot work miracles, but I was impressed enough with how it helped me to ask the question.
PS. You have been, and forever will be on "the good list"
As far as my sister in law, I can't really give any details. Ukranian medicine is not very open with information/ patent care. Two examples, my father in law had a stroke a year ago, and because they couldn't prove he didn't have Covid, they wouldn't admit him into the cardio wing, so he died a few days later from not receiving attention soon enough. Also, when giving birth, the baby is taken from the mother immediately, and the mother is isolated for 3-5 days. She can't see the baby or family. If she is lucky ( like my wife) and is on the ground floor with a window, her family can at least stand on the lawn and look in the window to see her, but not the baby. Needless to say, they never fully explained what exactly happened during the surgery and what, exactly, the brain damage was. She can function for typical everyday things like washing dishes and going to the store to buy treats, but has no concept of war and it's inherent dangers and why she is having to leave her home move to the US. She seems to have a high pain threshold. She didn't complain about her shoulder hurting until it was so bad it required reconstructive surgery, and didn't say anything about her teeth until her jaw was too badly damaged to accept normal dental implants. I understand Nubrainer cannot work miracles, but I was impressed enough with how it helped me to ask the question.
PS. You have been, and forever will be on "the good list"
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TimGDixon
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Re: NuBrainer
I knew I saw you...
Yeah thats some obstacles to overcome. Lets get her here and see what we might do to help her. I'm in.
Yeah thats some obstacles to overcome. Lets get her here and see what we might do to help her. I'm in.
“...never interrupt your enemy when he is making mistakes...”
Re: NuBrainer
Fantastic!!! They'll be arriving in North Pole on the 11th. If I start sounding strange after that, it's the Vodka.. too much or not enough!!! I'll start mom on the NB and QM ( 1 ea initially) a few days after arrival. I may have to start my " medication" about the same time. Best wishes from North Pole !!!
PS don't worry about the vodka on Xmas.... the Reindeer do all the driving!!
PS don't worry about the vodka on Xmas.... the Reindeer do all the driving!!